CNSC-25. METABOLISM ACROSS BRIDGE OF SIGHS TO ONCOHISTONES

Abstract Brain tumours continue to be one of the leading causes childhood mortality related cancers. Oncohistones such as H3K27M, and H3G34R mutations have been linked brain tumours. The reason for incidence Oncohistone mutation in a developmental setting provides some novel insight better therapeutics. maintenance progenitor state might driven by metabolism dictated at expense differentiation developing paving way tumourigenesis. I propose methods target metabolic disturbances even prior rise somatic oncohistone mutations. Additionally, provide into selective co-mutations that occur with specific providing rationale effective In 2021, proposed neuronal signalling an Hallmark cancer, context tumours, nervous system functions fulcrum between reprogramming epigenetic reprogramming. is lucrative inhibiting cues support oncohistones. Metabolic may underpin driving across Bridge Sighs towards